Abstract
Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)4 (12b) and NDGA-(triazol-glucose) 4 (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture. © 2010 Elsevier Ltd. All rights reserved.
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Hwu, J. R., Hsu, C. I., Hsu, M. H., Liang, Y. C., Huang, R. C. C., & Lee, Y. C. (2011). Glycosylated nordihydroguaiaretic acids as anti-cancer agents. Bioorganic and Medicinal Chemistry Letters, 21(1), 380–382. https://doi.org/10.1016/j.bmcl.2010.10.137
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