A haplotype of angiotensin receptor type 1 associated with human hypertension increases blood pressure in transgenic mice

Abstract

Background: AT1R activation induces oxidative stress, promotes inflammation, and increases blood pressure. Results: SNPs in AT1R promoter occur in linkage disequilibrium, forming two haplotypes. Transgenic mice with haplotype I have USF2-dependent AT1R overexpression, increased oxidative stress, and increased blood pressure. Conclusion: Haplotype I leads to enhanced expression and pathophysiological effects of AT1R. Significance: Polymorphisms in AT1R provide for genetic predisposition to hypertension. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.