Evaluation of Hemidesmus indicus Plant Compounds for Anti-Cancer Studies – An In silico Approach

Abstract

Background: Phytocompounds in medicinal plants have a wide range of properties and are alternative medicines for those who cannot be helped by conventional medicine. Objective: In this work we have selected bioactive compounds from Hemidesmus indicus medicinal plant extracts. Methods: Gas chromatography and Mass spectrum studies were studied to identify the compounds present in the ethanolic extracts based on the retention time and area. Results: The identified compounds were used for anti-cancer activity by insilico method with BCL-2 which plays prominent role in causing cancer. Conclusion: Out of twenty selected compounds, docking results showedMethyl-1-Cyclohexane carboxylate and 1,2-diacetoxy-5-idohexane as best docked to the BCL-2.