Electroanalysis of Flutamide as an Anticancer Drug at Electrochemically Activated Glassy Carbon Electrode

Abstract

Electrochemical oxidation of a glassy carbon (GC) electrode results in an oxygenated surface, which shows a good ability toward the electrochemical detection of flutamide (FLU). The oxidized electrode (GCox) can be accomplished easily and efficiently by electrochemical techniques. This procedure is fast, simple, and consists in applying a potential of -0.2 - 2.0 V vs. Ag/AgCl to a GC electrode. Modified electrodes were morphologically characterized by scanning electron microscopy (SEM) and the electrochemical activity of the GCox electrode was investigated using cyclic voltammetry (CV). Experimental parameters as pH, and scan rate were optimized for the electroanalysis of FLU. Under the optimized conditions, the GCox electrode showed a linearity from 0.05 to 0.6 mM of FLU. The limits of detection and the limit of quantification were calculated and the relative standard deviation was found to be 4.2%. The stability of the thus modified electrode within a suitable time showed an acceptable precision.