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Weight-loss-independent actions of GLP-1 medicines

Cell Metabolism
DOI: 10.1016/j.cmet.2026.07.006
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Abstract

The unprecedented broad efficacy of GLP-1 medicines reflects mechanisms beyond weight loss. GLP-1R agonism recruits neural and immune circuits, inter-organ communication, and engages local GLP-1Rs to improve cardiovascular, renal, hepatic, musculoskeletal, and organismal health. Defining dose-response relationships for weight-loss-independent mechanisms will facilitate optimization of the therapeutic potential of GLP-1 medicines.

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APA

Gonzalez-Rellan, M. J., & Drucker, D. J. (2026, August 4). Weight-loss-independent actions of GLP-1 medicines. Cell Metabolism. Cell Press. https://doi.org/10.1016/j.cmet.2026.07.006

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