Association of serum omentin-1 concentrations with the presence and severity of preeclampsia

Abstract

Background: Inflammation is involved in the pathogenesis of preeclampsia. Omentin is a newly discovered adipokine that possesses an anti-inflammatory function. The aim of this study was to determine the association of serum omentin-1 concentration with the presence and severity of preeclampsia. Methods: Serum concentrations of omentin-1 were measured in 128 women with preeclampsia and 96 women with uncomplicated pregnancies using an enzyme-linked immunosorbent assay method. Results: Patients with preeclampsia had significantly lower serum concentrations of omentin-1 compared to healthy controls. In addition, those patients with severe preeclampsia had significantly lower concentrations of serum omentin-1 compared to those with mild preeclampsia. Simple linear regression analysis showed that in patients with preeclampsia the serum concentrations of omentin-1 showed significant correlation with body mass index (P<0.001), systolic blood pressure (P<0.05) and homeostasis model assessment of insulin resistance (P<0.001). Conclusion: Decreased concentrations of serum omentin-1 appear to be associated with the presence and severity of preeclampsia.