FORMULATION, CHARACTERIZATION AND PHARMACOKINETIC EVALUATION OF NARINGENIN- LOADED GASTRORETENTIVE MUCOADHESIVE POLYMERIC NANOSYSTEM FOR ORAL DRUG DELIVERY

Abstract

ABSTRACT Nanoparticles mediated oral drug delivery system has attracted great attention in pharmacology to attain improved therapeutic index of chemotherapeutic drugs. In the present study, naringenin (NRG) - loaded gastroretentive mucoadhesive polymeric nanoparticles has been designed and investigated its application in oral drug delivery system. Naringenin loaded polymeric nanoparticles (NMPN) were prepared by thermal decomposition mediated nanoprecipitation method. Formulated NMPN were characterized and investigated for its mucoadhesive properties by swelling and in vitro mucoadhesion studies. The results indicated that the formulated NPMN were in the size of 66±7nm by dynamic light scattering analysis and the maximum drug loading efficiency was observed around 94.6±0.28%. Further the drug release studies showed that NMPN exhibited sustained drug release in stimulated gastric fluid (SGF; pH=1.2). Pharmacokinetic studies revealed that the formulated NMPN are highly biocompatible and showed enhanced therapeutic efficacy compared to free naringenin. The overall findings demonstrated that the gastroretentive mucoadhesive polymeric nanoparticles can act as a promising candidate with gastroprotective applications in biomedical research.