In Vivo Clastogenicity of Lead Chromate in Mice

Abstract

Cytogenetical effects of lead chromate were evaluated in vivo. When 0.5, 1, 2 and 4 g/kg body weight of lead chromate suspensions in 0.5% gum arabic were administered i.p. to C57BL/6N male mice twice, the frequencies of micronucleated polychromatic erythrocytes in the femoral bone marrow were significantly (p < 0.01) different from that in the vehicle control. Moreover, as the dose increased, the ratio of the polychromatic to normochromatic erythrocytes decreased in a dose-response fashion < 0.05). Thus, it is concluded that lead chromate in vivo gives rise to chromosomal damage as well as disturbance in hematopoiesis. lead chromate; chromosomal damage; micronucleus test; in vivo clastogenicity; hematopoiesis. © 1985, Tohoku University Medical Press. All rights reserved.