Xenon-enhanced computed tomography compared with [14C]iodoantipyrine for normal and low cerebral blood flow states in baboons

Abstract

The correlation between the acute, invasive diffusible [14C]iodoantipyrine technique for cerebral blood flow and the noninvasive xenon-enhanced computed tomographic method has been assessed by simultaneous measurements in the baboon. Blood flows in small tissue volumes (about 0.125 cm3) were directly compared in normal and low flow states. These studies demonstrate a statistically significant association between the two methods (p<0.001). Similar correlations were obtained by both the Kendall (r) and the Spearman (r) methods (r=0.67 to 0.92, n ≥ l9 for each study). The problems and limitations of such correlations are discussed. © 1990 American Heart Association, Inc.