Abnormal gait and motor cortical processing in drug-resistant juvenile myoclonic epilepsy

Abstract

Background: Juvenile myoclonic epilepsy (JME) is characterized by generalized seizures. Nearly 30% of JME patients are drug-resistant (DR-JME), indicating a widespread cortical dysfunction. Walking is an important function that necessitates orchestrated coordination of frontocentral cortical regions. However, gait alterations in JME have been scarcely investigated. Our aim was to assess changes in gait and motor-evoked responses in DR-JME patients. Methods: Twenty-nine subjects (11 JME drug-responder, 8 DR-JME, and 10 healthy controls) underwent a gait analyses during usual walking and dual-task walking. Later, subjects underwent 64-channel EEG recordings while performing a simple motor task. We calculated the motor-evoked current source densities (CSD) at a priori chosen cortical regions. Gait and CSD measures were compared between groups and tasks using mixed model analysis. Results: DR-JME patients demonstrated an altered gait pattern that included slower gait speed (p =.018), reduced cadence (p =.003), and smaller arm-swing amplitude (p =.011). The DR-JME group showed higher motor-evoked CSD in the postcentral gyri compared to responders (p =.049) and both JME groups showed higher CSD in the superior frontal gyri compared to healthy controls (p |–0.494|, p