230 Manganese guided cellular MRI of human embryonic stem cell viability

Abstract

Human embryonic stem cells (hESC) have demonstrated the ability to restore the injured myocardium. MRI has emerged as one of the predominant imaging modalities using iron-oxide nanoparticles to localize the transplanted cells in the myocardium. However, fundamental biological information regarding the viability of the transplanted cells can not be monitored. In this study, we employed MnCl2 (manganese chloride) guided cellular MRI to determine viability of hESC.