Bioactive metabolites from marine invertebrates

Abstract

Recent results in the chemistry of bioactive marine products are presented. Concerning the cytotoxic α-carbolines : grossularins A and B, the mechanism of the toxicity using supercoiled DNA and synthesis of the imidazolo-α-carboline moiety are presented. In the polysulfur compounds series, the structure of lissoclinotoxin B is proposed as well as a new synthesis of pentathiepins. Novel sesquiterpene sulfates from a Spongia sp. are described as p80cdc25 inhibitors. © 1994 IUPAC