Platelet-collagen interactions: Membrane receptors and intracellular signalling pathways

45Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Platelet adhesion to and activation by exposed subendothelial collagen plays a critical role in normal haemostasis and pathological thrombosis. Recent advances in elucidating the mechanisms underlying platelet-collagen interaction support a 'two-site, two-step' model. Direct platelet binding to integrin α2β1 mainly sustains adhesion and allows recognition of glycoprotein VI. The latter interaction is responsible for characteristic intracellular signalling events leading to p72Syk and PLCγ2 activation. The present review describes the known collagen receptors on platelets and discusses the current understanding of signal transdnction promoted by collagen.

Cite

CITATION STYLE

APA

Alberio, L., & Dale, G. L. (1999). Platelet-collagen interactions: Membrane receptors and intracellular signalling pathways. European Journal of Clinical Investigation. https://doi.org/10.1046/j.1365-2362.1999.00570.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free