Isolation and structure of spongilipid from the Republic of Singapore marine porifera Spongia cf. hispida

Abstract

Cell growth inhibitory (P388 lymphocytic leukemia) fractions from the purple marine sponge Spongia cf. hispida were employed to uncover a new biologically active monogalactosyl monoglyceride designated spongilipid (5a). The structure and absolute configuration of spongilipid was established by X-ray crystallography. Spongilipid specifically inhibited growth of the fecal opportunist Enterococcus faecalis.