IL-10, TNF-α & IFN-γ: Potential early biomarkers for preeclampsia

Abstract

The present study was designed to evaluate levels of IL4, IL10, TNF-α & IFN-γ at early second trimester and 24. h from delivery to assess potential correlation of cytokine variation with preeclampsia. A total of 176 consecutive healthy, normotensive primigravidas with uncomplicated singleton pregnancies were recruited at 14-18. weeks of gestation. Serum cytokine levels were estimated at recruitment and 24. h from delivery. In present study, 14(7.95%) women developed preeclampsia. Levels of IL-10, TNF-α and IFN-γ (Mean. ±. SE) at recruitment were statistically significantly lower in preeclamptic group (39.21. ±. 9.46. pg/mL, 73.57. ±. 13.37. pg/mL and 0.70. ±. 0.20. pg/mL, respectively) than non-preeclamptic group (86.02. ±. 4.55. pg/mL, 601.37. ±. 63.54. pg/mL and 1.67. ±. 0.08. pg/mL, respectively) (p<0.05). In preeclamptic group, IL-4 and TNF-α levels (Mean. ±. SE) were significantly higher 24. h from delivery (5.35. ±. 0.95. pg/mL and 381.21. ±. 43.28. pg/mL, respectively) than at recruitment (2.39. ±. 0.71. pg/mL and 73.57. ±. 13.37. pg/mL) (p=0.019 and 0.0001, respectively) while IL-10 and IFN-γ levels decreased after delivery but the change was not statistically significant. Therefore, the levels of IL-10, TNF-α and IFN-γ between 14 and 18. weeks of gestation may act as potential early biomarkers in the diagnosis of preeclampsia. © 2013 Elsevier Inc.