Deep Learning-Driven Intelligent Fluorescent Probes: Advancements in Molecular Design for Accurate Food Safety Detection

Abstract

The complexity of global food supply chains challenges public health, requiring advanced detection technologies beyond traditional lab methods. Fluorescent sensing, known for its sensitivity and quick response, is promising for food safety but hindered by inefficient probe design and difficulties in analyzing complex signals in food. Deep Learning (DL) offers solutions with its nonlinear modeling and pattern recognition capabilities. This review explores recent advancements in DL applications for fluorescent sensing. We explore deep learning methods for predicting fluorescent probe properties and generating fluorescent molecule structures, highlighting their role in accelerating high-performance probe development. We then offer a detailed discussion on the pivotal technologies of deep learning in the intelligent analysis of complex fluorescent signals. On this basis, we engage in a thorough reflection on the core challenges presently confronting the field and propose a forward-looking perspective on the future developmental trajectories of fluorescent sensing technology, offering a comprehensive and insightful roadmap for future research in this interdisciplinary domain.