Too many ends: Aberrant transposition

Abstract

A recent study by Zhang and colleagues published in the March 15, 2009, issue of Genes & Development (pp. 755-765) demonstrates that maize Ac/Ds transposons mediate translocations and other rearrangements through aberrant execution of the normal transposition process. Ac transposase uses one end from each of two neighboring elements in these events, which may happen more commonly than previously thought. In genomes where there can be many transposon ends scattered across all the chromosomes, such mistakes can have important consequences. © 2009 by Cold Spring Harbor Laboratory Press. .