Canonical notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis

17Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Although an essential role for canonical Notch signaling in generation of hematopoietic stem cells in the embryo and in thymic T-cell development is well established, its role in adult bone marrow (BM) myelopoiesis remains unclear. Some studies, analyzing myeloid progenitors in adult mice with inhibited Notch signaling, implicated distinct roles of canonical Notch signaling in regulation of progenitors for the megakaryocyte, erythroid, and granulocyte-macrophage cell lineages. However, these studies might also have targeted other pathways. Therefore, we specifically deleted, in adult BM, the transcription factor recombination signal-binding protein J k (Rbpj), through which canonical signaling from all Notch receptors converges. Notably, detailed progenitor staging established that canonical Notch signaling is fully dispensable for all investigated stages of megakaryocyte, erythroid, and myeloid progenitors in steady state unperturbed hematopoiesis, after competitive BM transplantation, and in stress-induced erythropoiesis. Moreover, expression of key regulators of these hematopoietic lineages and Notch target genes were unaffected by Rbpj deficiency in BM progenitor cells. (Blood. 2018;131(15):1712-1719)

Cite

CITATION STYLE

APA

Duarte, S., Woll, P. S., Buza-Vidas, N., Chin, D. W. L., Boukarabila, H., Luís, T. C., … Jacobsen, S. E. W. (2018). Canonical notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis. Blood, 131(15), 1712–1719. https://doi.org/10.1182/blood-2017-06-788505

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free