Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity

Abstract

Background. HLA genes play a role in the predisposition of several diseases. The aim was toanalyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU). Methods. 69 patients with AICU, and 200 healthy subjects. Results. Subjects with HLA-B44 and HLA-Cw5 antigens were morerepresented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4,and HLA-Cw7 antigen were more represented in control group than in patients with AICU. Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lowerrisk of AICU, whereas carriers of HLA-B44 phenotype had a higher risk of AICU. No differenceswere found between patients and controls as regards to HLA-DRB1* genotype. Conclusions. We observed an association between some HLA class-I antigens and AICU. To the best of ourknowledge this is the first description of such association. Copyright © 2006 Maria Luisa Pacor et al.