Potential dual effect anti-inflammatory and anti-platelet of cogon grass ethanol extract on diabetic mice a preliminary study

Abstract

Cogon grass is traditional medicine empirically used in nephritis, fever, hypertension, dyspnea, epitaxy, as a hepatoprotector agent, and has function to lower cholesterol and blood glucose. The compound of cogon grass is potentially served as an herbs medicine. But, the effect on haematology profile is still well unknown. We demonstrated the effect of cogon grass ethanol extract in mice model diabetic induced with STZ. Eight weeks old of male balb/c mice were injected intraperitoneally with STZ dose 130 mg/Kg BW. Seven days later, after DM confirmed, mice were given ethanol extract of cogon grass with dose 90 mg/KGBW (treatment group 1) and dose 115 mg/Kg BW (treatment group 2). After 14 days of extract gavage, haematology profile were estimated using the direct current detection method. We found there is no anemia occur in diabetic mice. But, the platelet and WBCs, were tend to increase in diabetic control group and treatment group 1, in contrast in treatment group 2 was tend to decrease. In conclusion, we suggested that the extract ethanol of cogon grass suppress the leukocyte and platelet count. It has potentially effect as anti-inflammatory and antiplatelet on diabetic mice.