Anti-Diabetic and Antihyperlipidemic Activities of Alternanthera Sessilis in Experimentally Induced Type 2 Diabetes

Abstract

The antidiabetic and antihyperlipidemic effects of ethanolic extract of whole plant of Alternanthera sessilis (EEAS) was investigated in Streptozotocin (STZ) induced type 2 diabetic rats. Diabetes was confirmed after 3 days of single intraperitoneal injection of STZ (35mg/kg) in albino Wistar rats. EEAS (100 and 200mg/kg) and glibenclamide (10mg/kg) orally administered daily for 15 days respectively, blood was withdrawn for glucose determination on 1, 7, 15 days respectively. On 15 th day, overnight fasted rats were sacrificed and blood was collected for determination of high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG). EEAS at doses of 100mg/kg and 200mg/kg showed significant reduction in blood glucose and lipid profiles when compared to diabetic control group. We concluded that EEAS possess antidiabetic and antihyperlipidemic activities.