Spices; a mechanistic anticancer treatise

Abstract

Spices are the promising and cost effective choice due to their high antioxidant activity, ability to triggers the free radicals scavenging ability at cellular level thereby alleviating various metabolic syndromes. They are good and enrich source of bioactive moieties such as curcuminoids, curcumin limonene, allicin, cinnamic aldehyde, 2-hydroxycinnamaldehyde, allyl isothiocyanate, eugenol, zingiberone, gingerol, dipropyle disulfides, and zingiberene, have been identified as chemo-preventing agents against various malignancies. Chemo-preventive properties of spices are mediated by functional bioactive ingredients that arrest the activity of cytochrome P450 and isozymes CYP 1A1, cyclooxygenase-2, reducing activator of transcription-3 (STAT-3) and signal transducer. They are closely associated with tumorigenesis activated by interleukin-6 (IL-6) receptors and epidermal growth factors (EGF) relate to an array of tumors. They altered the expression of protein involved in cell cycle, activating caspases killer and suppressing Kappa-B activation. The current review article explains the health endorsing perspectives of all spices and their daily use in life.