Nano drug delivery study of anticancer properties on ginger using QM/MM methods

Abstract

Ginger is a one of the most important foods which as an anticancer drug. It is well-known for its ability to shrink tumors. The anti-cancer properties were observed in addition to ginger's role in reducing inflammation, as well as being a rich source of life-enhancing antioxidants. Ginger has long been used in traditional medicine as a cure for some diseases including inflammatory diseases 1. Ginger contains active phenolic compounds such as gingerol, paradol and shogaol that have antioxidant 2,anti-cancer 3, anti-inflammatory 4, anti-angiogenesis 5 and anti-artherosclerotic properties 6 (Fig.2). In the present work, we investigated the potential anti-inflammatory and anticancer effects of ginger extract including gingerol, andshogaol jointed to nanotubeas dug delivery technics. So, we have used Gussian 98 methods for calculation via (B3LYP-MP2-) with 6-31g∗, basis sets .We has also studied NMR by changing the substituents in ginger for analyzing its properties.