Weight Drop Models in Traumatic Brain Injury

Abstract

Traumatic brain injury (TBI) is the leading cause of morbidity and mortality worldwide. TBI is often seen in people with loss of motor, cognitive and sensory function. TBI causes serious health problems such as death, disability and mental disorders. TBI continues to be an increasing health problem all over the world. It is estimated that approximately 1.7 million people suffer from head trauma each year and approximately 50,000 of these individuals die. Although TBI is seen in all ages and populations, the age population with the highest incidence is children and the elderly. Falls, sports activities and motor vehicle accidents are the biggest risk factors for TBI. To develop diagnosis and treatment methods for traumatic brain injury, the molecular and cellular mechanisms underlying neuropathology should be known. Therefore, different models of mild, moderate and severe experimental traumatic brain injury models are used. Animal models of traumatic brain injury are broadly classified as focal, diffuse, and mixed injury. Fluid percussion, controlled cortical effect, weight reduction and blast wave are the most preferred models in traumatic brain injury experimental research. This review describes the strengths and weaknesses of current rodent models for traumatic brain injury.