Regioselective hydration of alkynones by palladium catalysis

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Abstract

Diketones are regioselectively prepared from alkynyl ketones under mild conditions by palladium catalysis; 5-heptyn-2-one and 2-(2-nonynyl)cyclohexanone give 1,4-dikektones whereas 2-(2-heptynyl)cyclopentanone and 5,6-didehydroprostaglandin E2 methyl ester afford 1,5-diketones. © 1987.

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Imi, K., Imai, K., & Utimoto, K. (1987). Regioselective hydration of alkynones by palladium catalysis. Tetrahedron Letters, 28(27), 3127–3130. https://doi.org/10.1016/S0040-4039(00)96302-0

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