Moringa oleifera decrease blood sugar level and blood pressure in pregnant diabetic rats

Abstract

It has been known that 10% of pregnancy will undergone diabetes and increases the risk of hypertension, premature birth, intrauterine growth disorders, perinatal death, kidney and liver failure, pre-postpartum hemorrhage, and maternal death. Many treatment regimen had been use however still there were no satisfied result. Recently, Moringa oleifera was popular as miracle tree that had many health properties. Many paper had report its anti-cancer properties, antipyretic, antiepileptic, anti-inflammatory, antiulcer, antispasmodic, diuretic, antihypertensive, antioxidant, antidiabetic, hepatoprotective, antibacterial, antifungal, antiatherosclerotic, heart and blood circulation stimulant. Hence we conduct this research to dig the role of moringa oleifera in diabetic pregnant rat. We used 30 pregnant rats divided into 6 groups of treatment, i.e two control group and others were treatment group of different doses of Moringa powder at 100, 200, 400 and 800 mg/day/kg. Alloxan 150 mg/day/kg was used to induce diabetic animal model. Blood glucose was measure using glucostick methods and blood pressure was measure using the tail-cuff method using CODA blood pressure analyzer. In this study, it can be concluded that the administration of Moringa leaf powder (Moringa oleifera) at a dose of 200 mg/day/kg BW decreased glucose levels and decreased blood pressure at a dose of 400 mg/day/kg BW on in diabetic pregnant animal model.