Antimicrobial activities of some pyrazoline and hydrazone derivatives

Abstract

Objectives: Resistance to antibiotics is recognized as one of the biggest threats to human health worldwide. Frequent and unnecessary use of antibiotics has caused infectious agents to adapt to antibiotics and thus drugs have become less effective. The resistance to many antibiotics necessitates the discovery of new antibiotics. In this study, two new and 23 previously reported 2-pyrazoline derivatives and one hydrazone derivative were evaluated for their in vitro antibacterial and antifungal activities. Materials and Methods: For the determination of the minimum inhibitory concentration (MIC) values of compounds, microbroth dilution was used. Results: The antimicrobial activities of the compounds were found in a wide range with MIC values of 32-512 μg/mL. Conclusion: The synthesized compounds showed moderate antimicrobial activity compared with the standards. They can be used as lead molecules for the synthesis of more effective compounds.