Anticonvulsant effect of the fruit essential oil of Cuminum cyminum in mice

Abstract

In this study, the anticonvulsant effect of the fruit essential oil of Cuminum cyminum Linn. (Umbelliferae) was studied against seizures induced by maximal electroshock (MES) or pentylenetetrazole (PTZ) in mice. Administration of the essential oil protected mice against MES- and PTZ-induced tonic seizures. Furthermore, at some anticonvulsant doses, the essential oil produced sedation and motor impairment.