Fighting with Aging: The Secret for Keeping Health and Longevity of Naked Mole Rats

Abstract

Health and longevity are the dreams of mankind and the main field of the medical community. The naked mole rat (NMR) is a unique murine animal with extremely long lives (exceeding 38 years), revealing little signs of aging such as reproductive decline, neural degenerative diseases, and cancer. They provide us with valuable perspectives on preventing age-related diseases. This review systematically summarized the characters of different systems of naked mole rats in aging resistance, and furtherly exploited the mechanisms for aging resistance form genome, telomeres, protein recycling, metabolism, and oxidative stress attitudes. As a species with a high similarity with human beings, it cannot be ruled out that after reasonable validity, safety and ethical evaluation, the dominant genes of naked mole rats will be developed in medical transformation, to realize the dream of human health and longevity.