Susceptibility profiles of amphotericin B and posaconazole against clinically relevant Mucorales species under hypoxic conditions

Abstract

The effect of hypoxic conditions on the in vitro efficacy of amphotericin B and posaconazole against Mucorales was evaluated by defining MICs with Etest and broth microdilution and identifying minimal fungicidal concentrations (MFCs). with Etest, oxy-gen- dependent changes were detected, while the MIC and the MFC determined with broth microdilution remained unaltered with reduced oxygen levels. The observed differences depended on the method used.