Induction of FcεR2/CD23 on human epidermal Langerhans cells by human recombinant interleukin 4 and γ interferon

Abstract

Human rIL-4 and human rIFN-γ are able to induce the expression of the low affinity receptor for IgE (FcεR2/CD23) on normal human epidermal Langerhans cells, whereas IL-2 and PMA have no effect. A synergistic effect is observed when both cytokines are combined. These receptors are synthesized de novo by the LC since cycloheximide completely inhibits the appearance of FcεR2/CD23. Fcεr2/CD23+ LC may have a major role in the pathogenesis of atopic eczema, as well as in the regulation of IgE synthesis.