Atg7 in AML: A double-edged sword?

Abstract

In this issue of Blood, Piya et al have identified the autophagy-related E1 ligase Atg7, a critical autophagy component associated with unfavorable outcomes in acute myeloid leukemia (AML), as a potential target in this disease.1 If validated, this study could provide a foundation for disrupting Atg7 in AML therapy.