Studies of the spontaneous movement of animals by the hole cross test; effect of 2-dimethyl-aminoethanol and its ACYL esters on the central nervous system

Abstract

Smaller changes of spontaneous movement in mice after the single administration of smaller doses of methamphetamine, caffeine, reserpine, and chlorpromazine which can not be found by usual methods for a separate animal, can be detected by the hole cross apparatus. DMAE and some of its acyl esters have two different actions on the spontaneous movements in mice; depression and excitation can be seen a short time after the single administration. The recovery of the depressed spontaneous movement of the reserpinized mice can be recognized after the single injection of DMAE and its acetate. © 1971, The Japanese Pharmacological Society. All rights reserved.