Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome - the core splicing machinery - that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors.
CITATION STYLE
Anczuków, O., & Krainer, A. R. (2015). The spliceosome, a potential Achilles heel of MYC-driven tumors. Genome Medicine, 7(1). https://doi.org/10.1186/s13073-015-0234-3
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