Two year result of intravitreal bevacizumab for diabetic macular edema using treat and extend protocol

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Abstract

To determine the efficacy of the treat and extend (TAE) protocol with intravitreal bevacizumab (IVB) for managing diabetic macular edema (DME). Retrospective, single-center study. For this retrospective study, 42 eyes of 42 patients were initially treated with 3 consecutive monthly IVB injections (loading phase), after which they were selected for different additional therapies. For the TAE protocol, the baseline treatment interval was selected to be 8 weeks and was sequentially lengthened by 2 weeks if the central macular thickness (CMT) was <300μm at 2 consecutive examinations. Among the 42 eyes, 8 eyes (19.0%) received the TAE treatment for 2 years. The BCVA was improved significantly from 0.37±0.04 before treatment to 0.19±0.04 logMAR units at 2 years after the TAE determined IVB injections (P

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Sugimoto, M., Ichio, A., Nunome, T., & Kondo, M. (2017). Two year result of intravitreal bevacizumab for diabetic macular edema using treat and extend protocol. Medicine (United States), 96(16). https://doi.org/10.1097/MD.0000000000006406

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