[Hydroxy(tosyloxy)iodo]benzene mediated α-azidation of ketones

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Abstract

Reaction of various ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment of the α-tosyloxy ketones thus generated in situ with NaN3 offers a one-pot procedure for the synthesis of α-azido ketones. The HTIB used in this conversion may also be generated in situ by using iodosobenzene in combination with p-toluene-sulphonic acid. © 2006 by MDPI.

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Prakash, O., Pannu, K., Prakash, R., & Batra, A. (2006). [Hydroxy(tosyloxy)iodo]benzene mediated α-azidation of ketones. Molecules, 11(7), 523–527. https://doi.org/10.3390/11070523

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