Bilirubin adsorption column Medisorba BL-300

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Abstract

Bilirubin adsorption column Medisorba BL-300 (Kuraray Medical Inc.) for the treatment of hyperbilirubinemia is introduced. The adsorbent packed in this column is the porous anion exchange resin coated with hydrophilic 2-hydroxyethyl methacrylate copolymer in order to improve blood compatibility. The adsorbent showed a high adsorption rate for direct bilirubin and indirect bilirubin in patient plasma in vitro. This column is used in plasmaperfusion therapy in clinical use, BL-300 showed high removal rate for direct bilirubin, indirect bilirubin and bile acid in clinical evaluation. BL-300 is approved in Japan and it has been used for the treatment of hyperbilirubinemia caused by many diseases such as liver failure and hepatitis.

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Nakaji, S., & Hayashi, N. (2003). Bilirubin adsorption column Medisorba BL-300. Therapeutic Apheresis, 7(1), 98–103. https://doi.org/10.1046/j.1526-0968.2003.00007.x

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