CD137 as a biomarker for tumor-reactive T cells: Finding gold in the desert

Abstract

Although human cancer is often surrounded by immune cells, only a small number are tumor-reactive T cells that recognize the tumor antigens and are able to eliminate the cancer cells. Ye and colleagues now found that many of these tumor-reactive T cells are marked by expressing CD137, a T-cell costimulatory receptor. Clin Cancer Res; 20(1); 3-5. © 2013 AACR.