Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition

Abstract

Katsumadain A, a naturally occurring influenza virus neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner-Wadsworth-Emmons/oxa Michael addition. © 2013 Wang et al.