Association of mmp-7-181a>g polymorphism with colorectal cancer and gastric cancer susceptibility: A systematic review and meta-analysis

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Abstract

Introduction: The matrix metalloproteinase-7 (MMP-7) gene-181A>G polymorphism has been reported to be associated with colorectal cancer (CRC) and gastric cancer (GC) susceptibility, yet the results of these previous results have been inconsistent or controversial. Aim: To elaborate a meta-analysis to assess the association of-181A>G polymorphism of MMP-7 with CRC and GC risk. Methods: Published literature evaluating the association from PubMed, Web of Science, Google Scholar and other databases were retrieved up to April 25, 2018. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random-or fixed-effects model. Results: A total of 19 case-control studies, which included eleven studies on CRC (2,169 CRC cases and 2,346 controls) and eight studies on GC (1,545 GC cases and 2,366 controls) were identified. There was a significant association between MMP-7-181A>G polymorphism and GC risk under the homozygote model (GG vs. AA: OR=1.672, 95% CI 1.161-2.409, p=0.006) and the recessive model (GG vs. GA+AA: OR=1.672, 95% CI 1.319-2.554, p=0.001), but not with CRC. By subgroup analysis based on ethnicity, an increased risk of CRC and GC was found only among Asians. Conclusions: This meta-analysis suggests that MMP-7-181A>G polymorphisms is associated with GC risk, but not with CRC. However, our results clearly showed that the MMP-7-181A>G polymorphism significantly increased the risk of CRC only in Asians.

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Zare, M., Jafari-Nedooshan, J., Aghili, K., Ahrar, H., Jarahzadeh, M. H., Seifi-Shalamzari, N., … Neamatzadeh, H. (2019). Association of mmp-7-181a>g polymorphism with colorectal cancer and gastric cancer susceptibility: A systematic review and meta-analysis. Arquivos Brasileiros de Cirurgia Digestiva. Colegio Brasileiro de Cirurgia Digestiva. https://doi.org/10.1590/0102-672020190001e1449

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