A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289

Abstract

Objective: This study aimed to investigate the tumor circular RNA_0018289 (circ_0018289) expression and its correlation with clinical characteristics as well as survival profiles in cervical cancer patients. Methods: A hundred and ninety-two cervical cancer patients who received surgical resection were recruited in this prospective study. Tumor tissue and paired adjacent tissue were obtained during the surgery, in which circ_0018289 expression was detected by reverse transcription quantitative polymerase chain reaction. Disease-free survival (DFS) and overall survival (OS) were recorded. Results: Circ_0018289 expression was upregulated in tumor tissue compared with paired adjacent tissue (P