Effects of cypermethrin on the hematological parameters, biochemical components of blood and histopathological changes in different organs of chirruh snow trout (schizothorax esocinus)

Abstract

The current study describes effect of different concentrations of cypermethrin on hematological parameters, biochemical components of blood, histopathological changes in different organs and DNA damage in Chirruh snow trout Schizothorax esocinus. WBCs, RBCs, hemoglobin, hematocrit, MCV, MCH, MCHC and platelets were significantly decreased in all treated groups compared to control. Monocytes showed significant increase in all experimental groups. Lymphocytes counts significantly decreased in all treated groups compared to control groups. Neutrophils count increased significantly in all treated groups. Among electrolytes, sodium and potassium levels were increased, whereas, calcium and phosphorous levels decreased in all treated groups. From amongst biochemical components of blood triglycerides, cholesterol, urea and protein level decreased, whereas in the glucose level increased in all treated groups. In histopathology, dose dependent lesion and alterations in gills, liver, brain, kidney, intestine and muscles related with oxidative stress damage was observed. Genotoxicity increased with increase in time and concentration of cypermethrin. Cypermethrin is therefore extremly harmful to aquatic life.