A Review of the Genetic Effects on Appetite Regulation: An Obesity Perspective

Abstract

Obesity is a worldwide epidemic. It is a medical condition in which abnormal or excessive fat has been accumulated to present health risks including diabetes, hypertension, heart disease and several cancers. Obesity is a multi-factorial health issue that is related to a combination of causes, such as behavior, genetics, and environment. It is important to explore the genetic factors and metabolic pathways in the precise treatment of obesity. Base on the summary of twin studies, this paper discussed the pathophysiological abnormalities that genetically affect obesity and the role of appetite regulation in addressing obesity. Obesity affects every major system of human body, so it is of great significance to understand its mechanism and carry out effective prevention and treatment.