Synthesis of some novel methylene-bis-pyrimidinyl-spiro-4-thiazolidinones as biologically potent agents

Abstract

(Chemical Equation Presented) A series of novel methylene-bis-pyrimidinyl- spiro-4-thiazolidinones 6a-h have been synthesized by cyclocondensation of thioglycolic acid with methylene-bis-(N-cyclohexylidene-N-pyrimidine) 5a-h, which in turn have been prepared by the reaction of cyclohexanone with methylene-bis-2-aminopyrimidines 4a-h, which are prepared by the reaction of guanidine hydrochloride with methylene-bis-chalcones 3a-h. The compounds 3a-h have been synthesized by the reaction of 5-(3-formyl-4-hydroxybenzyl)-2- hydroxybenzaldehyde 2 with various acetophenones in presence of KOH. The compound 2 is prepared by the reported method. The structures of the compounds synthesized have been confirmed by their elemental analysis and spectral data. Their antibacterial and antifungal activities have also been evaluated.