One-pot synthesis of tetrasubstituted imidazoles catalyzed by preyssler-type heteropoly acid

Abstract

A simple one-pot four-component synthetic method was reported for the preparation of tetrasubstituted imidazole derivatives from benzil, aromatic aldehydes, primary amines and ammonium acetate in the presence of Preyssler-type heteropoly acid catalyst. This method was proved to be ecobenign, easy work-up, convenient, relatively short reaction times and the products were isolated with high yields.