A REVIEW ON THERAPEUTIC APPLICATION OF GARLIC (ALLIUM SATIVUM L.) TO HUMAN HEALTH BENEFIT IN VARIOUS DISEASES

Abstract

Garlic (Allium sativum L.) is one of the best medicinal herb. It is frequently used since time as a food and a culinary spice. Garlic also stands as the second most utilized supplement. The chemical constituent of garlic bulb contains a highe r concentration of sulfur compounds called organosulfur compound (OSC). Garlic and Its products are used as sources of medicine in many ways in human be ings in their day today life. The OSCs like allicin, diallyl, mono,di, tri, tetra, hexa and hepta sulfides, vinyldithiins and ajoenes which are wate r and lipid soluble responsible for its medicinal effects. Higher consumption of Allium products is associated with reduced risk of several type s of cance rs as per epidemiological studies. This paper is re viewed on the biological responses of OSCs have been largely attributed to reduction of cardiovascular disease, cancer, lowe ring of cholesterol by alte ring HDL/LDL ratios, antiparasitic, antiprotozoal, antimicrobial and antioxidant effe cts, inhibits plate le t aggregation and enhances fibrinolytic activity reducing clots on damaged endothelium. Ajoe ne is another compound seems to be responsible for its anti-clotting effect.