Catalytic asymmetric cross-couplings of racemic α-bromoketones with arylzinc reagents

Abstract

(Chemical Equation Presented) Nickel box: The first catalytic asymmetric method for cross-coupling arylzinc reagents with α-bromoketones has been developed (see scheme). This stereoconvergent carbon-carbon bond-forming process occurs under unusually mild conditions and without activators, thereby allowing the generation of potentially labile tertiary stereocenters. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.