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Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40

British Journal of Cancer (2009) 100(1) 113-117
DOI: 10.1038/sj.bjc.6604812
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Abstract

SGN-40 is a therapeutic antibody targeting CD40, which induces potent anti-lymphoma activities via direct apoptotic signalling cells and by cell-mediated cytotoxicity. Here we show antibody-dependent cellular phagocytosis (ADCP) by macrophages to contribute significantly to the therapeutic activities and that the antitumour effects of SGN-40 depend on Fc interactions. © 2009 Cancer Research UK.

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APA

Oflazoglu, E., Stone, I. J., Brown, L., Gordon, K. A., Van Rooijen, N., Jonas, M., … Gerber, H. P. (2009). Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40. British Journal of Cancer, 100(1), 113–117. https://doi.org/10.1038/sj.bjc.6604812

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