4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation

Terry V. Hughes; Stuart L. Emanuel; Amanda K. Beck; Steven K. Wetter; Peter J. Connolly; Prabha Karnachi; Michael Reuman; Jabed Seraj; Angel R. Fuentes-Pesquera; Robert H. Gruninger; Steven A. Middleton; Ronghui Lin; Jeremy M. Davis; David F.C. Moffat

Journal Article

4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation

Bioorganic and Medicinal Chemistry Letters (2007) 17(12) 3266-3270

DOI: 10.1016/j.bmcl.2007.04.021

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Abstract

A novel series of 4-aryl-5-cyano-2-aminopyrimidines were synthesized and found to have potent VEGF-R2 kinase inhibitory activity. Structure-activity relationships were investigated and compound 14a was shown to be efficacious in a mouse model of corneal neovascularization. © 2007 Elsevier Ltd. All rights reserved.

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Hughes, T. V., Emanuel, S. L., Beck, A. K., Wetter, S. K., Connolly, P. J., Karnachi, P., … Moffat, D. F. C. (2007). 4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation. Bioorganic and Medicinal Chemistry Letters, 17(12), 3266–3270. https://doi.org/10.1016/j.bmcl.2007.04.021

4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation

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