The anticancer peptide LL-III binds with nanomolar affinity to human telomeric and cMyc G-quadruplexes

Abstract

LL-III is a natural anticancer peptide able to cross the membrane of cancer cells and to localize in the nucleolus, but its intracellular target is unknown. Here, we show that LL-III is able to bind with nM affinity to specific G-quadruplex structures known to be relevant anticancer targets.